Author(s) Details:
Avraham Mayevsky
The Mina & Everard Goodman Faculty of Life Sciences, Bar-Ilan University, Ramat-Gan 5290092, Israel.
Michael Tolmasov
The Mina & Everard Goodman Faculty of Life Sciences, Bar-Ilan University, Ramat-Gan 5290092, Israel.
Mira Mandelbaum
The Mina & Everard Goodman Faculty of Life Sciences, Bar-Ilan University, Ramat-Gan 5290092, Israel.
This section is a part of the chapter: Real Time Assessment of Patients’ Body Oxygen Balance and Tissue Metabolic Score (TMS)
The functional capacity of any tissue is related to its ability to perform its work. It is possible to assess this ability through the knowledge of changes in the oxygen balance, i.e. the ratio of oxygen supply to oxygen demand in the tissue. According to our long-term experience; the “holy grail” of patients’ monitoring at the various physiological compartments is to keep positive tissue oxygen balance ensuring optimal mitochondrial function. A schematic presentation of the balance between oxygen supply and demand in a typical tissue is shown in Fig. 1 (Mayevsky et al., 2018). The supply of oxygen is dependent upon microcirculatory blood flow (TBF), blood volume (TBV) and the level of oxygen bound to the hemoglobin (HbO2) in the small blood vessels, namely, in the microcirculation (Meirovithz et al., 2007). The level of oxygenated hemoglobin in the microcirculation is affected by two factors, namely, oxygen consumption by the mitochondria and the microcirculatory blood flow. The demand for oxygen is affected by the specific activities taking place in each organ (Mayevsky et al., 2018). The intracellular level of mitochondrial NADH (the reduced form) is a parameter related to oxygen balance (Mayevsky & Chance, 1982; Mayevsky & Rogatsky, 2007).
How to Cite
Mayevsky, A., Tolmasov, M., & Mandelbaum, M. (2025). Real Time Assessment of Patients’ Body Oxygen Balance and Tissue Metabolic Score (TMS). Medical Science: Trends and Innovations Vol. 4, 101–142. https://doi.org/10.9734/bpi/msti/v4/4146